Histomorphological study of placenta in women with Polycystic Ovarian Syndrome

Abstract

Abstract newlineHistomorphological study of placenta in women with PCOS sought to analyze the impact of BMI (low and newlinehigh) on polycystic ovarian syndrome pregnant womenand#8223;s (PCOS) materno-placento-fetal characteristics. newlinePCOS is a commonly occurring endocrinopathy affecting reproductive aged women. PCOS and obesity newlineexhibits overlapping characteristic features. Since, body mass index (BMI) is the most prominent risk newlinefactor influencing prevalence of pregnancy complications in PCOS, this study aimed to ascertain the newlineimpact of BMI (25) on PCOS and non PCOS pregnant womenand#8223;s materno- placento-fetal features which newlineincludes placental macroscopic and microscopic examination, fetal birth weight and pulse, maternal TSH newlineand Hb level. Results reveal that PCOS placenta independent of BMI exhibits variation in shape, umbilical newlinecord insertion, fibrosis, hematoma, calcification and villitis. In regard to the placental anthropometric newlinefeatures, variation in weight, length and thickness was obvious, clearly describing increased BMI positively newlineinfluencing weight and thickness while negatively influencing length in both. Similarly BMI also impacts newlinethe fetus but in a distinct fashion in the case of fetal birth weight and similar fashion for fetal pulse. Then newlinein the context of maternal TSH and Hb, PCOS per se found to increase TSH and decrease Hb; along with newlineincreased BMI found to significantly increase TSH and decrease Hb. Overall, this study result concludes newlinethat compared to normal subjects, BMI impacts more the PCOS subjectand#8223;s maternal, placental and fetal newlinecharacteristics. It is suggesting the need for more care and attention in the management of pregnant newlinewomen with PCOS overlapped with high BMI for the successful pregnancy outcome.Our present study newlinefocused to investigate the placental alterations, subsequently observed results were correlated with newlinematernal and fetal characteristics to understand the impact of PCOS on placenta and the associated newlineoutcomes.