Investigation on metal oxide based nanocomposites for drug delivery application

Abstract

Nanotechnology is having its unique properties due to its design, newlinecharacterization, fabrication and application-based structures that have physical, newlinechemical and biological properties by controlling shape and size at the nanometre newlinescale. It has also created an excellent platform in the areas of disease detection, newlinecontrolled drug delivery, biosensors, tissue engineering and biomedical newlinehundred nanometres and so they are anywhere from the size of an antibody to the newlinesize of virus. The drug delivery system was effectively used in therapeutic newlineapplications by the researchers, however there are certain issues that need to be newlineresolved. Drugs with poor solubility, low clearance rate, poor bioavailability and newlineless diffusion are the limitations of the currently available commercial drugs and newlinethe limitations can be overcome by the application of nanotechnology newlineapproaches in drug delivery system. Nanocarriers are made by various materials newlinesuch as lipids, protein, composite polymers, metals and semiconducting newlinematerials. To enhance the activity of nanoparticles like biocompatibility, poor newlinedrug loading, pharmacologically deficient drug concentration at the target site newlinesurface modification is a must for better action. newlineTherefore, in the present research the focus is on the importance of newlinesurface modification of nanoparticles for a better therapeutic efficacy. It has newlinebeen demonstrated in increasing the particle interaction with the targeted newlinetissues and has become a highly promising strategy. The nanomaterials like newlineZinc Oxide (ZnO), Iron Oxide (Fe3O4), Mesoporous Silica (SiO2) and newlinepolymers like PMMA (Poly Methyl Methacrylate), Chitosan (CS) and PEG newline(Poly Ethylene glycol) have been chosen which are highly biocompatible and newlinenatural. Synthetic polymers offer excellent potential for biological newlineapplications particularly in the field of drug delivery. newline