Comparative Evaluation Of Antifungal Activity Of Neem Leaves Extract In Combination With Selected Herbal Oils In Topical Formulation

Abstract

newline Abstract newline200 newlineABSTRACT newlinePhytochemistry of various reported antifungal plants has evidenced that; phytochemicals newlinepossibly will be a better source of effective and potential medication as compared to newlinesynthetically created drugs. Therefore, with the boundless interest to bring out screening newlineof medicinal plants to expose techniques and active principle, systemic screening and newlinenew methods to develop formulations may result in the discovery of unique active newlinecompounds that can be employed for the treatment of dermatological conditions. newlineNatural medicines of herbal origin are still used as the potent therapeutic agents, newlineparticularly to treat fungal, bacterial, viral, parasitic infections, etc. This research is newlinefocused on the use of Neem plant leaves extract with the selected oils with prominent newlineantifungal and antibiofilm action that will act in a synergistic way in a stable newlineformulation to prevent and cure common topical fungal infections viz. Candidiasis and newlineTinea. By the recent years, there has been a gradual revival of concern in the use of newlinemedicinal plants in developing countries because herbal medicines have been reported newlinesafe with negligible adverse side effect especially when compared with synthetic drugs. newlineIn accord with the scenario the current study is carried out with the following objectives; newlineand#61623; To select the specific plant and herbal oils with prominent antifungal action. newlineand#61623; To study the antifungal potential of Neem leaves extract and selected essential oils newlinecombinationss against selected fungal strains. newlineand#61623; To standardize the dose of leaves extract and essential oils combination against newlineselected fungal strains. newlineThe antifungal activity of neem leaves (Azadirachta indica) ethanolic extracts in newlinecombination with A. indica, Eucalyptus citriodora and Cymbopogon martini essential newlineoils was conducted by agar well diffusion method followed by M38-A2 broth newlinemicrodilution method on pathogenic dermatophytes strains; Microsporum gypseum, newlineTrichophyton mentagrophytes and T. rubrum. Neem leaves extract was obtained by newlinet