Studies on Multi Component Reactions for the Synthesis of Biologically Active Compounds

Abstract

Studies on multi-component reactions for the Synthesis of Biologically Active Compounds. newlineChapter 1: Synthesis of 1-phenyl isoquinoline derivatives and synthesis of newline4,4 (arylmethelene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols). newlineSection 1.1: Synthesis of 1-phenyl isoquinoline derivatives. newlineSection 1.2: Synthesis of 4,4 (arylmethelene) bis (3-methyl-1H pyrazol-5-ols). newlineChapter 2: Synthesis of Quinoxaline derivatives. newlineSection 2.1 : Synthesis of Quinoxaline from ortho phenelene diamine and phenacyl newlinebromide. newlineSection 2.2 : Synthesis of Quinoxaline from ortho phenelene diamine and 1,2 newlinediketones. newlineChapter 3: Synthesis of Pyrido [2,3-d : 6,5-d] dipyrimidine and Spiro-oxoindole newlinederivatives newlineSection 3.1 : Synthesis of Pyrido [2,3-d : 6,5-d] dipyrimidine derivatives newlineSection 3.2: Synthesis of Spiro-oxoindole derivatives newlineChapter 4: Synthesis of 3 methyl 4 - benzyl methelene-isoxazol 5(4H) ones newlineand Dielectric Dispersion study of Isoxazol Derivatives with binary newlinemixtures of DMSO. newlineSection 4.1 : Synthesis of 3 methyl 4 - benzyl methelene-isoxazol 5(4H) ones. newlineSection 4.2 : Dielectric Dispersion Study of Isoxazol Derivatives with Binary Mixture newlineof DMSO. newlineChapter 5: Biological activity of synthesized compound. newlineSection 5.1 : 3 methyl- 4 - benzyl methelene-isoxazol 5(4H) ones. newlineSection 5.2 : 4,4 ( aryl methelene) bis (3-methyl-1-phenyl-1H-Pyrazol-5 ols) newlinederivatives newlineSection 5.3 : 1-Phenyl isoquinoline derivatives newlineSection 5.4: Synthesis of Spiro-oxoindole derivatives newlineSection 5.5 : Pyrido [2,3-d : 6,5-d] dipyrimidine derivatives newlineABSTRACT newlineIn the present work, we have synthesized bioactive heterocyclic compounds using green protocol as well as drastic conditions in multistep reactions and their biological activities have been studied. The work is divided into five chapters. newlineThe first chapter includes the synthesis of 1-phenyl isoquinoline derivatives and synthesis of 4,4 ( aryl methelene) bis (3-methyl-1-phenyl-1H-Pyrazol-5 ols) derivatives and it is divided into to two sections. Section 1 describes the extraordinary ruthenium cata