Investigation on Surface Functionalized Mesoporous Silicon Dioxide Sio2 Nanoparticles Fabricated with Reduced Graphene Oxide Rgo Nanosheet for Targeted Drug Delivery on Breast Cancer Cells

Abstract

Mesoporous nanoparticles (MNPs) have gained considerable attention in the biomedical field as trustworthy drug delivery systems for the treatment of cancer. Due to their high surface area, tunable pore size, huge pore volume, simplicity in adjusting the interior and exterior surfaces, and high drug loading potential, they have a number of benefits over conventional drug carriers. Synthesis of mesoporous silicon dioxide nanoparticles (MNPs) with different pore volumes and their toxicity effects on zebrafish. The structural and morphological analyses of MNPs were carried out through XRD and HRTEM, functional groups have been identified by FTIR and N2 adsorption/desorption isotherm and the pore size distribution was determined by BET analysis. The maximum pore volume of 1.5 cm3/g and a pore size of 8.0 nm, were reported. Survival percentage of zebrafish was reported to be above 85% newline