Synthesis of new metal complexex and their interaction with CT DNA

Abstract

newline Medicinal inorganic chemistry a sub discipline of bioinorganic chemistry is one of the most rapidly developing areas of pharmaceutical research This field gained momentum after the prototypical success story of platinum based anticancer drug cisplatin cis diamminedichloro platinum II cis Pt NH3 2Cl2 for treating solid cancers in particular testicular ovarian small cell lung head and neck cancers Despite its success there were serious concerns of this drug regarding its toxicity intrinsic resistance narrow spectrum of activity for phenotypes of cancer and patient compliance Therefore studies pertaining to essential metallo elements received much more attention in contrast to Pt since the drugs designed and synthesized from endogenous metal ions may be less harmful and more prone to antiproliferative activity against tumors Consequently a large number of metal complexes have been designed and are currently under evaluation for chemotherapeutic applications Many studies have been done to elucidate the mechanism of action as well to elucidate the mechanism of action as well as to optimize and improve the activity in comparison to platinum drugs