Phytochemical and Pharmacological Investigation on Tephrosia Purpurea Ficus Glomerata Ficus Religiosa in Animal Models

Abstract

In technical terms, the inflammatory response directs immune system components to the site of injury or infection and is manifest by increased blood supply and vascular permeability which, in technical terms, allows chemotactic peptides, neutrophils, and mononuclear cells to leave the intravascular compartment. Microorganisms are engulfed by phagocytic cells (e.g., neutrophils and macrophages) in an attempt to contain the infection in a small-tissue space. The response includes attraction of phagocytes in a chemotactic gradient of microbial products, movement of the phagocyte to the inflammatory site and contact with the organism, phagocytosis (ingestion) of the organism, development of an oxidative burst directed toward the organism, fusion of the phagosome and lysosome with degranulation of lysosomal contents, and death and degradation of the organism. When quantitative or qualitative defects in neutrophil function result in infection, the infection usually is prolonged and recurrent and responds slowly to antimicrobial agents. Staphylococci, gram-negative organisms, and fungi are the usual pathogens responsible for these infections. Purpose of In-vivo Models of Inflammation is to provide the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. In conclusion, the present study reveals that T.Purpurea F.religiosa and F. glomerata and their fractions showed the presences of diverse phytochemicals which are responsible for the different pharmacological activities of the drugs. In the present study T.Purpurea, F.religiosa and F. glomerata showed better analgesic, anti-inflammatory activity however T.Purpurea F.religiosa and F. glomerata showed good activity in arthritis, cancer and hyperlipidemic model. The extracts have the potential safety and efficacy advantages for anti-cancer chemoprevention as well as utility for treating malignant disease if combined with chemotherapy.