Study on Evaluation of Molecular Markers for Buccal Mucosa Cancer

Abstract

Oral cancer is the sixth leading cause of morbidity and mortality in world and newlinesecond leading disease in India. Of all oral subsites, buccal is the most aggressive in nature newlineobserved with increasing incidence over the last 15 years in India. Most of the cancers of newlineoral cavity are squamous cell carcinoma. Five years survival rate of buccal mucosa cancer newlinehas remained at approximately 50%, despite advance in multimodality treatments in last few newlinedecades. Therefore, the failure of conventional therapies underscores the need to identify newlinenovel molecular targets that can improve the prognosis and therapeutic possibilities newlineassociated with buccal mucosa cancer. newlineThere is mounting evidence that alterations of cell death processes are involved newlinein cancer pathogenesis. The current research is focusing on type-II programmed cell death newline(autophagy) signaling network, which involves in a cellular degradation process, had newlineparadoxical roles in tumorigenesis and the progression of human cancers. Hence, we newlinehypothesize autophagy signaling markers in buccal mucosa cancer patients newline