Evaluation of some medicinal plants for Immunomodulatory and anti Filarial activity in rodent model

Abstract

Investigation of immunomodulatory or therapeutic efficacy in three selected Indian medicinal plants namely, Annona squamosa (AS), Murraya koenigii (MK), Withania somnifera (WS) chemotype and Withania coagulans (WC).The present study is aimed at exploration of immunomodulatory activities of these plants in naïve BALB/c mice against filariasis.The immunomodulatory efficacy of these plants was explored in vitro and in vivo by analyzing the humoral and cellular immune responses, Th1/ Th2 cytokines and activation of antigen presenting cells after administering these test samples in BALB/c mice. The present findings demonstrate that among the four plants selected in the present study, AS and WS 101R proved to be the best immunostimulants. Active constituents (compounds 1, 2 and 5 of AS and withanone, withanolide A and withaferin A of WS 101R)have been identified. Among the identified pure molecules, compound 5 of AS and withaferin A proved to be the best immunostimulants. newline