Genotoxic effects of tobacco and modulatory effects of flavonoids on Methotrexate induced genotoxicity

Abstract

The influence of lifestyle on health has been the issue since industrialization and newlinehas tremendously hampered the human populace. The usage of tobacco in different newlineforms is one such issue that may lead to Cancer. There are many environmental agents newlinewhich may bring various effects on the genetic material of human beings and other newlineexposed organisms. Such genotoxic compounds may bring about various harmful effects newlineincluding cancer. Thus, genotoxicity is one of the significant endpoints for risk newlineassessment of various lifestyle factors. newlineSince centuries Tobacco (Nicotiana tabacum) in different forms is being used by newlineIndians. People in India consume more of chewing tobacco and because of this habit newlinethere is an increase in the disease burden in our population. Smokeless tobacco usage is newlinegetting more popularized across the world. Its usage predominates in women in South newlineEast Asia as a safe alternative for smoking. Since recent insights into public health newlineemphasize, the tobacco use as a lifestyle risk factor for different cancers, it is important newlineto explore the harmful consequences of this exposure. newline