pharmacological evaluation of different herbal extracts on acute pancreatitis in rats

Abstract

The aim of the study was to evaluate the protective effects of fruit extracts of five selected plants against L-arginine induced Acute Pancreatitis in Male Sprague Dawley rats. newline Acute pancreatitis (AP) is a rapid inflammatory condition of the exocrine pancreatic tissue with high mortality. The condition of the disease may vary from mild self limiting to severe form where the diagnosis and progression of the disease assessment is complicated. The incidence rates annually for acute pancreatitis ranges from 13 to 45 per 1, 00,000 people and chronic pancreatitis from 5 to 12 per 1, 00,000 people worldwide. The differentiation in the incidence rate is not evidently understood between the geographical locations but most probably replicate the difference in prevalence of risk factors. There is a rising incidence of acute pancreatitis first attack with increase in hospitalization rate. The incidence of acute pancreatitis is subclinical and mortality may be seen even before the exact identification. Many etiological factors contribute to the generation of AP, where alcohol and gall stones are the major ones. The Pathophysiology of the disease is complicated and not implicit, but many hypothesis have been suggested based on the reports of the researchers. The disease has been characterized by premature activation of digestive enzymes which lead to disturbance of balance between apoptosis and necrosis leading to triggering of inflammatory mediators. The most accepted theory is the involvement of reactive oxygen species which sets a local inflammatory response that can be eventually be converted in to a systemic response eventually. The treatment of AP is mostly supportive with fluid resuscitation and prevention of malnutrition, since no specific therapies are available and posing a challenge to health care professionals. Thus, the present study was designed to address the problem of pancreatitis.