Development and Optimization of Microemulsion Based of Transdermal Drug Delivery For Paroxetine Hydrochloride

Abstract

Background: Paroxetine is the most potent serotonin reuptake blocker antidepressant. This study is aimcd to reduce the conscqucnces accompanied with the preliminary high plasma concentration after oral administration of drug and fluctuations in plasma levels and additionally in imitation to minimize broad metabolism of the drug in the liver by flourishing and optimizing transdermal formulation of paroxetine hydrochloride in order to improve its bioavailability and safety. Aim: The aim of this work was to design and evaluate a microemulsion transdermal gel of Paroxetine Hydrochloride for the treatment of depression. Objectives: In this study, paroxetine hydrochloride microemulsion transdermal gel was developed and evaluated as a potential antidepressant. The most potent serotonin reuptake blocker that can be used as antidepressants is paroxetine. Materials and Methods: Paroxetine HCI microemulsions gel were developed using the phase-titration method, D-optimal design and factorization. The microemulsion region was chosen using a pseudo -ternary phase diagram, and the % of oil, surfactant and co-surfactant in the finished product were optimised. Formulations were produced and evaluated for several specifications, such as a Fourier-transform infrared spectroscopy (FTIR) Compatibility test between the drug and the excipient, based on phase diagrams. The developed transdermal microemulsion gel underwent testing for size distribution, zeta potential, Differential scanning calorimetry (DSC), % Cumulative drug release (CDR), % transmittance, Globule size, C1max, Tmax, drug content, in-vitro diffusion, and ex-vivo permeation tests. Key Outcomes: The physicochemical properties of the ParoOxetine HCI formulations of microemulsion-based gel were determincd to be completely favourable. The optimised formulation demonstrated drug release of around 79.23% for almond oil and 65% for flax seed oil in 8 hours, passed thermodynamic stability test, and was DEPARTMENT OF PHARMACEUTICS, GLOCAL UNIVERSITY, SAHARANPUR U.P PAGE i ABSTRACT