HLA DRB1 shared epitope alleles and non HLA gene polymorphisms as risk factors for rheumatoid arthritis

Abstract

A significant elevation in laboratory measures was observed in rheumatoid arthritis patients compared to controlsand#61472;The frequency of HLA DRB1 01 04 10 and 14 is found to be more with autoantibodies positive RA patientsand#61472;The HLA DRB1 07 08 11 13 and 15 alleles were less frequent in rheumatoid arthritis patients and found to be significantly increased in control group as compared to patients indicating a possible protective effect and#61472;The frequency of CTLA4 CT60 A allele and padi 4 90T carriers was significantly higher in rheumatoid arthritis patients and also it is preferentially observed in SE positive rheumatoid arthritis patients and#61472;The frequency of CD244 T allele carriers was significantly higher in RA patients and it is independent of SE positive RA patients We found significant association of the susceptible AT haplotype and RA patients The AC haplotype is found to be significantly increased in control group compared to rheumatoid arthritis patients and#61472;The AT haplotype of PADI4 gene was significantly associated with 1 2 copies and the AC haplotype was significantly associated with 2 copies of HLA DRB1 SE alleles in RA patientsand#61472;and#61472;The combination of non HLA allele frequency ATCAGC is found to be associated with increased RA susceptibility while ACCGGC is significantly reduced and confer protection against RA disease and#61472;In RA patients the ATCAGC frequencies of non HLA gene was increased with 1 and 2 copies of HLA DRB1 SE alleles when compared to 0 copy of HLA DRB1 SE alleles and#61472;The combined allele frequency of non HLA risk variants ATCAGC showed an increased frequency in the autoantibodies RF and anti CCP positive RA patients newline