Biological evaluation of dipeptide coated magnetic nanoparticles in lung cancer models under pulsed electromagnetic field

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dc.contributor.guideGanesh Venkatraman
dc.coverage.spatialRadiology
dc.creator.researcherGanga Baskar
dc.date.accessioned2018-06-04T09:31:17Z
dc.date.available2018-06-04T09:31:17Z
dc.date.awarded28/05/2018
dc.date.completed28/05/2018
dc.date.registered01/07/2009
dc.description.abstractnewlineThe purpose of the study was to establish enhanced cellular uptake of dipeptide coated magnetic nanoparticles in vitro and in vivo in lung tumor cells and to test the suitability of the magnetic nanoparticles in inducing localized hyperthermia in a pulsed electromagnetic field magnetic nanoparticles were synthesized by co precipitation method and characterized by transmission electron microscopy dynamic light scattering and vibration sample magnetometer the effect of the magnetic nanoparticles on cellular viability was assessed in and was found to be non cytotoxic to lung cancer cells In vitro cellular uptake of the magnetic nano particles in lung cancer cells and in vivo bio distribution in a tumor xenograft model were confirmed by Prussian blue staining and inductively coupled plasma optical emission spectrophotometer the magnetic nanoparticles were tested for heating effects in a pulsed electromagnetic field and its effect on cellular morphology viability and expression of heat shock and apoptotic markers were assessed in lung cancer cells the magnetic nanoparticles in the presence of induced cell death in lung cancer cells
dc.description.noteIntroduction p.1 40 Materials and Methods p.41 55 Results p.59-68 Discussion p. 68-71 Summary and conclusion p.122 123
dc.format.accompanyingmaterialNone
dc.format.dimensions15cms
dc.format.extent1-155
dc.identifier.urihttp://hdl.handle.net/10603/205286
dc.languageEnglish
dc.publisher.institutionCollege of Biomedical Sciences
dc.publisher.placeChennai
dc.publisher.universitySri Ramachandra University
dc.relationnil
dc.rightsself
dc.source.universityUniversity
dc.subject.keywordDipeptide
dc.subject.keywordHyperthermia
dc.subject.keywordIron oxide
dc.subject.keywordLung cancer
dc.subject.keywordPulsed electromagnetic field
dc.titleBiological evaluation of dipeptide coated magnetic nanoparticles in lung cancer models under pulsed electromagnetic field
dc.title.alternative
dc.type.degreePh.D.

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