Role of Yoga and its possible mechanism involved in type 2 diabetes mellitus related DNA damage and repair A randomized control trial

Abstract

BACKGROUND newlineType-2 diabetes (T2D) is becoming one of the fastest-growing major non-communicable newlinediseases (NCDs) adversely affecting human life and well-being globally, in a multitude of newlineways. The latest epidemiological data shows its worldwide prevalence as 463 million and is newlineprojected to reach 700 million by 2045. At the molecular level, T2D condition is associated newlinewith a higher level of oxidative stress (OS), reduced antioxidant capacity, increased oxidative newlineDNA damage, and impaired DNA damage-repair capability, which may lead to a variety of newlinemicro and macrovascular diseases, endothelial dysfunction, atherosclerotic plaques, and newlinesubsequent development of cardiovascular diseases and stroke. Although yoga is found to be newlinebeneficial in the management of T2D, its mechanism of action is poorly understood. This newlinestudy examines how yoga modulates OS induced DNA damage and the efficiency of DNA newlinerepair in T2D condition newlineAIMS AND OBJECTIVES newlineThis study aims to elucidate how yoga influences oxidative DNA damage, its repair, and newlinethereby overall DNA damage in T2D patients. and#61623; To assess the effect of yoga practices on DNA damage and repair in patients with T2D newlineand#61623; To investigate the mechanism of action involved in the effect of yoga practices on DNA newlinedamage in patients with T2D newlineMETHODS newlineParticipants newlinePatients identified with T2D (fasting plasma glucose above 126 mg/dL, as per American newlineDiabetic Association guidelines), age ranging from 35 to 60 from both genders (Male:33, newlineFemale:28) and having no prior yoga experience were enrolled using convenience sampling newlinefor this study. newlinev newlineDesign newlineThis study followed a randomized control trial design (RCT), where, T2D subjects (n=61), newlineaged (Mean ± SD, 50.3 ± 4.2)were randomly allocated into Yoga group (31) that received 10 newlineweeks of yoga intervention and Control (30) with routine exercises. newlineAssessments: newlinePrimary outcome measures; newlineTM: Tail Moment and OTM: Olive Tail Moment (indices of DNA damage) newline8-OHdG: 8-hydroxy-2 -deoxyguanosine as Oxidative DNA damage marker, newlineOGG1: 8-Oxoguanine glycosylase - protein expr