Non Enzymatic Antioxidant Status in Oral Cancer Patient

Abstract

Conclusions: An increased MDA, deficient antioxidant vitamins as well as iron levels, and long-term inflammation caused by smokeless tobacco, particularly gutkha, may be regarded as risk factors for oral cancer. Measurement of serum MDA, vitamin A, E, C, and iron levels might help in assessing tumor grades and thus might help in prediction and prevention of OSCC. The low antioxidant and/ micronutrient levels could be either a cause or effect of oral cancer or due to tobacco-chewing habit. OSCC was found to have association with increased MDA, low serum antioxidant and/ micronutrient profile of vitamin A, E, C, and iron. Therapeutic measures to increase antioxidants, along with routine anticancer therapy and improving dietary intake of micronutrients are warranted. Further studies using a larger sample size and longterm follow-up of subjects are desirable.