Mathematical Modeling of Biomarker and Performance Analysis of Nanodevice as Biosensor for Cancer Detection

Abstract

Biosensors with biomarkers containing Deoxyribo Nucleic Acid (DNA) or antigen-antibody which identify DNA strands or specific antigen in blood sample of tissues. Initial screening of cancer prevents future human loses. It is motivating and interesting to design and fabricate the biosensor to identify the cancer cells in its initial stage of occurrence. By using existing resources tools of open source and simulators, researchers are now capable to design, model as well as to simulate the biosensors for performance evaluation before fabrication. The application of mathematical knowledge and modelling into biosensor field give a vision on its design. The extensive literature review is done on different types of nanobiosensors and analysing their characteristics to detect cancer. The main objective of this research work is to mathematical newlinemodel biomarker, biosensor and performance analysis of nanobiosensor for cancer detection. With the mathematical model and using simulation, the appropriate test cases are applied to validate. Using nanohub.org the varieties of sensors are modelled and simulated for their performances. The model is simulated to detect cervical cancer. Carbon Nano Tube Field Effect Transistor (CNTFET) based electronic circuits have been designed and integrated with viii biosensors. CNTFET models have been obtained from Stanford Nanotechnology Centre and the models have been used to develop electronic circuits. The modeling and simulation of electronic circuits have been verified using HSpice.The analytical model is based on self-consistent solutions of Diffusion-Capture model for time response, Poisson-Boltzmann and drift-diffusion equations for electrolyte screening and newlineconductance modulation and the statistical properties of bio-molecule absorption for selectivity. newlineNanowire and CNTFET have played a significant role in the detection of cervical cancer with HPV biomarker. Here, modelling and analysis of Nanowire and CNTFET sensor structure for HPV biomarker is analysed for their performance. A sensor array model using CNTFET is newlineplaced in 64 arrays with reference bias voltage is designed to improve the sensor sensitivity by increasing the drain current. The sensor is modelled using nanohub.org and the sensor array is newlinemodelled in Hspice for analysis. The developed sensor and sensor array can be used for cervical cancer detection. Properties of Single Wall Carbon Nano Tube and Multi Wall Carbon Nano Tube of 30 nm length and semi-conducting behaviour are analysed. Single Wall Carbon Nano Tube is applicable for biosensor applications due to its high current carrying capability. The Cancer Specific Antigen in the blood sample data is identified using DNA strands. The mathematical model and simulated model developed in this work exhibit positive result for cervical cancer detection. newline