Studies on Borylation Reactions Hydro and Carboboration of Alkynes and Borylation of Carboxylic Acids

Abstract

Organoboron compounds have found wide applications in the formation of novel C-O, C-C and C-N bond via transition metal-catalyzed reactions. The hydroboration and carboborylation of carbon-carbon multiple bonds is one of the robust methodologies to introduce the boron atom into the organic framework. Traditionally, borane species were used in the borylation reaction (Hydroboration, and carboborylation) of alkynes under transition metal free conditions for synthesis of vinylboronate intermediates. When employing precious metal catalyst such as palladium and, rhodium in the reactions, the scope of borylation as well as the regio- and stereoselctivity in the reaction enhanced. In recent years, the non-precious 3d- metal catalysts such are nickel, cobalt, iron and copper were widely used in the borylation reaction of alkynes especially in improvement of selectivity. Alkenyl boronates have extensive applications in organic synthesis. These are utilized in various coupling reactions to form new carbon-carbon bonds, facilitating the synthesis of complex molecules. Additionally, alkenylboronates play a crucial role in drug design, with potential applications in pharmaceutical research. Furthermore, alkenylboronates exhibit significant biological effects, particularly in anti-cancer studies contributing to ongoing research efforts in the development of novel therapies. newlineThe thesis entitled Studies on Borylation Reactions: Hydro- and Carboboration of Alkynes and Borylation of Carboxylic Acids presents our efforts toward comprehending the regio- and stereoselective borylation reactions of alkynes and carboxylic acids, employing various base metals as catalysts. Mechanistic studies have been conducted to elucidate newline