Development Evaluation and Optimization of Chronomodulated Drug Delivery Systems by Various Approaches for Antihypertensive Drugs

Abstract

Controlled drug delivery systems (DDS) are cutting-edge technologies for transporting pharmaceutical substances throughout the body, and they are critical for improving medicine efficacy. To provide the optimal therapeutic benefit, it enhances the solubility and bioavailability of pharmaceuticals while reducing side effects. The goal of any drug delivery system was to provide the therapeutic amount of drug to the proper site in the body also to achieve and maintain the desired drug concentration in blood. Improving the therapeutic efficacy of existing drugs has been tried by different technologies. One of the effective technologies exiting in recent years of pharmacy is Chrono drug delivery system. Pulsatile drug release is a system where the drug is released suddenly after a well-defined lag time or time gap according to the circadian rhythm of disease states. No drug is released from the device within this lag time. This delivery system is suitable in cases where drugs including proteins and peptides undergo great metabolic degradation. The identification of drug was carried out by FTIR spectroscopy and meltingpoint. The physicochemical parameters such as appearance, solubility study and loss on drying were performed by suitable methods. The analytical profile of drug was evaluated for determination of absorption maximum, development of standard curve and percentage purity of drug. Compatibility of drug and polymer mixture was done by performing DSC study. It was concluded that there was no interaction between the drug and polymer. According to stability study it was found that there was no variation in Bulk density, Tapped density, Thickness , Hardness , Friability , Weight variation, drug content and In-Vitro drug released was nearly 94.13%.in lag time for part I formulation and Percentage yield, Entrapment efficiency, and in vitro drug released profile for part II formulation. The formulation OF4 for part I and NF3 for part II was concluded best formulation among the formulations were prepared.