Synthesis of Heterocyclic Compounds and their Evaluation for Biological Activity

Abstract

In this thesis we have designed and developed novel biological active heterocycles hybrid with different pharmacophores. Further we have evaluated the different biological activity of all the synthesized compounds. We investigated the compounds biosensing ability for detection of important biomarkers such as human serum albumin protein and bovine serum albumin protein for early detection of diseases such as liver disease, renal disease etc. through different spectroscopic methods using UV and Fluorescence spectrophotometer. We also investigated the mechanism of interaction of the active compound towards both the analytes. The next biological activities that we explored is antibacterial activity of the synthesized indole/naphthalimide appended benzimidazole and quinoxalinone hybrids. Further we investigated most potent compounds for different bacterial strains. The mechanism of action of most potent compounds were investigated. newline