a retrospective study of the clinicopathological profile of colorectal carcinoma and its correlation with markers of microsatellite instability at a tertiary care center

Abstract

newlineTo study the immunohistochemical expression of markers of newlinemicrosatellite instability (MSI) in colorectal cancers and correlate newlinethe findings with clinicopathological factors. newlineOBJECTIVES newline1. To tabulate the age and gender characteristic of cases of newlinesurgically resected specimens of colorectal carcinoma newlinereceived at our institute . newline2. To list out the gross features, site in the colon and laterality newlineof the colorectal carcinoma cases. newline3. To tabulate the histological features, grade and stage of the newlinecolorectal carcinoma cases. newline4. To perform the immunohistochemical markers of newlinemicrosatellite instability (MLH1, MSH2, MSH6, PMS2) in the newlinerepresentative tissue sections of colorectal carcinoma cases. newline5. To study the expression of markers of microsatellite newlineinstability (MLH1, MSH2, MSH6, PMS2) in the newlinerepresentative sections of tissues. newline6. To correlate the microsatellite stability/instability status with newlinedemographic features and tumour characteristics such as site, newlinemorphology, grade, pathological stage, presence of tumour newlinedeposits, lymphovascular and/or perineural invasion