Synthesis Electrochemical and Pharmacological Studies of Some Modified Drugs

Abstract

In recent years, there has been significant focus on developing new, efficient, and safe newlinemedications using economically viable, environmentally friendly, and innovative synthetic newlineapproaches, aiming to achieve long-term sustainability. The increasing pressure to avoid the newlineuse of dangerous organic solvents, reagents, and complex synthetic processes in organic newlinereactions has raised concerns among researchers regarding health, safety, and environmental newlineissues. As a result, there is a growing need to find safe and user-friendly methods for newlinesynthesizing biologically valuable compounds. At the moment, researchers are prioritizing the newlinedrug repurposing technique to create novel pharmaceuticals by utilizing pre-existing drugs on newlinethe commercial market, instead of attempting to synthesize new medicines from raw materials, newlinewhich is a laborious and expensive process. This approach requires fewer resources and newlinefacilitates the speedy production of new bioactive lead molecules. newlineThe main objective of this thesis is to employ the concept of medication repurposing to develop newlinepotent medicinal derivatives with reduced undesirable characteristics. The development of newlinethese derivatives will be based on commercially accessible active pharmaceutical intermediates newline(APIs), namely Metformin hydrochloride, Diclofenac sodium, and Irbesartan. The currently newlinesynthesized novel derivatives are examined utilizing thin-layer chromatography (TLC) and newlinespectroscopic techniques. The glucosidase inhibitory activity of the structurally newlinemodified metformin derivatives is being assessed in relation to metformin. The anti-inflammatory newlineefficacy of diclofenac derivatives was evaluated by in vivo animal tests and the newlinemorphology of all the derivatives were determined using the powder X-ray diffraction newlinetechnique. newline