Physicochemical Study of Antioxidant Surfactant Interaction: utilization in clotrimazole topical formulation

Abstract

Micellar systems hold excellent drug delivery applications due to their capability to solubilize a large number of hydrophobic and hydrophilic molecules In this present work, the mixed micelle formation between three surfactants SDS, CTAB and Triton X 100 and two synthetic lipophilic antioxidants BHA and BHT have been studied in different alcohols and hydroalcoholic mediums ie 100percent 70 percent and 30 percent of MeOH, EtOH and 1 PrOH Early micellization was found with critical micelle concentration CMC shifting towards lower concentration In this context, conductance study, CMC, standard thermodynamic parameters of micellization namely , and have been evaluated at different temperatures Molar volume and compressibility measurements have also been carried out to evaluate the apparent molar volume and#61542;v and apparent molar adiabatic compression and#61542;k of BHA BHT surfactant complex and discussed in terms of the solute solute and solute solvent interactions newline