Development of ortho nosyloxy as a novel coupling reagent for peptide synthesis and related organic transformations

Abstract

We developed a reagent coupling reagent ethyl 2 cyano 2 2 nitrobenzenesulfonyloxyimino acetate ortho NosylOXY and its application for the synthesis of amides esters peptides hydroxamates N protected amino acid based benzoxazoles and benzothiazoles and nitriles The whole structure of the thesis is depicted in scheme 1 Firstly we have developed a method for the synthesis of o NosylOXY and its application for racemization free synthesis of amides and peptides Secondly we established a met