Superparamagnetic Customizable Drug Delivery Devices from SPIONs Functionalized with Nanocellulose and Chitosan for Targeted Cancer Therapy by Magnetic Hyperthermia and Magneto Responsive Doxorubicin Delivery Design Synthesis and In vitro Biofunctional Performance Evaluation

Abstract

Despite extensive research advancements in cancer therapy, the newlinemedical community continues to grapple with formidable challenges in newlinethe treatment and eradication of cancer that accounts for one-sixth of newlinehuman deaths. Newer non-invasive and patient-friendly cancer treatment newlinemodalities are of utmost importance owing to the severe side effects newlineassociated with conventional therapeutic approaches, viz. surgery, newlinechemotherapy, and radiotherapy. Stimuli-responsive drug delivery and newlinemagnetic hyperthermia are two such treatment methods gaining increased newlineclinical attention. The former works on the principle of internal and newlineexternal stimuli-driven release of chemotherapeutics while the latter newlineinvolves artificially elevating the tumour tissue temperature to 41-43 ºC. newlineThis study is focused on the design and development of four customizable newlinestimuli-sensitive drug delivery devices capable of eliciting hyperthermia newlinefor cancer treatment. Superparamagnetic iron oxide nanoparticles (SPIONs), newlinesurface-functionalized with nanocellulose and chitosan, were employed newlinefor formulating these systems where magneto-responsive drug delivery newlineis established with doxorubicin (DOX) as the model drug. Initially, newlinesuperparamagnetic cellulose nanofibers with pH-dependent drug release newlineand hyperthermia potential were prepared by an in situ synthesis (from newlineAgave sisalana plant leaf fibers), for deep-seated chemotherapeutic newlineapplications. Glyoxal crosslinked superparamagnetic and porous chitosan newlinemicrospheres were then designed, which are able to release the drug in newlinea controlled manner via degradation-dependent diffusion. newline