Isolation and characterization of bioactive metabolites produced by actinomycetes associated with coastal lichens of tamil nadu

Abstract

Multidrug-resistant (MDR) microorganisms are causing an increased newlinenumber of infections, and the resulting Antimicrobial Resistance (AMR) poses newlinea global health challenge, exacerbating the need for novel bioactive compounds newlineand antibiotics. The most sought after biotechnologically important molecules newlinehave been obtained from terrestrial actinomycetes. Several terrestrial newlineactinomycetes have been extensively studied and are nearing the limits of their newlinediscovery potential. This has led to a focus on more quirky and under-studied newlineecosystems such as marine environments. Coastal lichen are of unique habitat newlineand their potential for novel actinomycetes screening remains largely newlineunexplored, these organisms occupy a unique ecological niche, and their newlinecollective diversity is unparalleled. These lichens, resulting from a symbiosis newlinebetween fungus and photobionts, are also reported to harbor endophytic newlineactinomycetes capable of synthesizing novel chemical entities. However, the newlinetransient production of these metabolites and the difficulties associated with the newlinelarge-scale cultivation of microorganisms under optimized conditions are newlinecrucial to maximizing metabolite production. There is a critical need for newlinesystematic exploration and optimization of endophytic actinomycetes from newlinecoastal lichens to discover novel bioactive compounds, that could serve as newlineeffective therapeutics against resistant pathogens and other diseases. newline