Study of sequence dependent insitu peptide cyclization and its applications as biomolecules

Abstract

The peptides are gaining escalating recognition due to its progress in the area of biotechnology and bioengineering. The work presented in the thesis mainly centred on the design and synthesize of side chain modified peptides which can form cyclic peptide in situ at the physiological condition without the need for any external reagents in-vitro. Further, the cyclization concept has been applied to release bioactive molecules and also to inhibit the protein aggregation. Peptides are early leading for the realistic design to deliver bioactive molecules as they can provide target specificity, potency, resistance towards chemical or enzymatic hydrolysis and longer resident times for more effective duration of action to improve biological efficacy and minimize side effects. In the second chapter, a quick conversion of a