Development Of AntiDiabetic Oral Tablet By Using Functional Polysaccharides

Abstract

The number of people affected by diabetes is increasing at an alarming rate and is newlineexpected to cross 366 million in 2030 from 171 million in 2000. There are number of newlineherbs that are reported to possess antidiabetic activity. Many amongst them possess newlinesubstantial amount of mucilage or polysaccharides. There are literatures that indicates newlinethat the mucilage extracted from those plant have inherent the therapeutic activity of the newlineplant. Mucilage or polysaccharides find their application in food and pharmaceutical newlinesector as excipients. The aim of this research work is to develop antidiabetic activity of newlinefew selected oral hypoglycemic agents using the mucilage extracted from plants showing newlineantidiabetic activity. The hypothesis of this study lies in the fact that the mucilage or newlinepolysaccharides will inherit the antidiabetic activity and will potentiate the activity of newlineformulations. Fenugreek seed, okra pod and leaves of Hibiscus rosa-sinesis was selected. newlineMucilage was extracted from these sources by precipitation with ethanol, acetone and newlineethanol respectively. The extracted mucilage was subjected to various physicochemical, newlinephytochemical and micromeritic tests and the results indicates that these mucilages can newlinebe used for formulation of tablets. Glipizide and metformin was selected as model drug newlinefor formulation of tablet. These drugs belong to different category of antidiabetic drugs. newlineFactorial design was applied to design tablets. Amount of extracted mucilage and amount newlineof microcrystalline cellulose was varied and 32 factorial design was applied. New set of newlineformulations were also prepared varying the amount of drug and mucilage applying 32 newlinefactorial design. The prepared tablets were subjected to various test. The results were newlinecompared with the limits prescribed in United States Pharmacopoeia and found that newlineparameters of each batch of tablets were within acceptable limits. The prepared tablets newlineii newlinewere subjected to in-vivo antidiabetic activity. Streptozotocin was used for inducing newlinediabetes in rats. The antidiabetic activity reveals that the formulations containing reduced newlineamount of OHA (glipizide and metformin) was showing much reduced blood glucose level newlinecompared to blood glucose levels of rats treated with OHA. This can be attributed to the newlinefact that the mucilage may have potentiated the activity of formulations. It can be newlineconcluded that the mucilage extracted from natural resources can be used as excipients newlinefor formulation of tablets. These mucilages were showing promising antidiabetic activity newlineand can potentiate the therapeutic activity of the formulations. These mucilages when newlineused as an excipient for formulation of antidiabetic tablets serve dual purpose. They newlineimpart stability to the formulation as well as enhance the antidiabetic activity of the newlineformulation. This provides an opportunity to reduce the amount of synthetic drug. newline