Towards understanding the expression and regulation of gper1 and its significance thereof in human breast cancer

Abstract

G Protein Coupled Estrogen Receptor 1 GPER1 is a novel membrane associated estrogen receptor and a major player in the short term non genomic actions of estrogen GPER1 signaling is implicated in various estrogeninfluenced physiological and pathological conditions including breast cancer However the clinical significance of GPER1 and regulation of its expression in breast cancer is not completely understood particularly considering the contribution of the nuclear estrogen receptors The th