design synthesis and evaluation of some heterocyclic compounds as anticancer agents

Abstract

The research work entitled Design, Synthesis and Evaluation of Some Heterocyclic Compounds as Anticancer Agents is divided into 7 chapters mentioned in brief as follows. newlineA new series of hydroxamic(5a-5j) and carboxylic acid analogues(4a-4j) based on the 1,3,4- thiadiazole scaffold are designed and synthesized with the aim of exploring its potential as new antitumor agents. The chemical structures of the compounds were confirmed on the basis of TLC,IR, 1H NMR and 13C NMR analysis. Molecular docking studies showed that the target compounds bind into the binding pocket of histone deacetylase inhibitor in the same manner as reference compound (PDB Code 1w22 reference compound)whilt their ,drug likeness was predicted to be acceptable. The predicted physicochemical were compared with those of reference compound. Biological results revealed that the structural modifications proposed significantly affected inhibitory potency. Compounds were significantly more active with IC50 values in the low micromolar . Selected compounds was tested on the viability of MDA-MB- 231 (breast cancer cell) and K562 (chronic myelogenous leukemia cell), A549( human lung cancer) ,PC3 (Prostate cancer cell lines) using MTT assay. newline