Development of Controlled Release Long Acting Microspheres to Treat Chronic Ailments

Abstract

Chronic conditions requrre prolonged treatment. However, traditional oral dosage forms and simple injections necessitate multiple administrations, leading to patient discomfort and dose fluctuations. Microsphere formulations offer a superior approach to managing chronic conditions, allowing for weeks to months of drug release with a single administration. This study focuses on the development and evaluation of pramlintide and naltrexone microsphere formulations. newlineCurrently, pramlintide acetate is available in solution form and is indicated for advanced stages of diabetes, requiring co-administration with insulin after major meals via subcutaneous injection. This frequent need for multiple daily injections can significantly inconvenience patients, highlighting the advantages of microsphere formulations newline