Hepatoprotective role of herbal extract against pesticide toxicity

Abstract

Glufosinate Ammonium caused biochemical and histopathological liver damage in newlineWistar rats. The significant changes were noticed on body weight pattern as well as newlinethe biochemical parameters which is the evidence of toxicity According to these newlineresults, it is suggested that systemic pesticides exposure might cause hazardous newlineeffects; especially at high doses to non-target organisms, including humans. However, newlineprecautionary measures should be put in place during field application to circumvent newlinepossible adverse effects on consumers, who are increasingly being exposed to newlinecontamination from food and drinking water. The coadministration of Eucalyptus newlineglobulus extract attenuated the toxic effect of pesticide. Therefore, administration of newlineEucalyptus globulus extract may be useful, easy, and economical to protect humans newlineexposed to Glufosinate Ammonium against their toxic effects. Thus it may act even in newlinehumans as important constituent in potent liver tonic. Further studies should be newlineconducted to identify the active components responsible for these activities and newlinedetermination of synergistic effects among various compounds present in the extract. newlineTherefore, a comprehensive study is essential before a long term exposure. newlineSection A deals with the quality control parameters and in vitro screening of Herbal newlinepreparations. In the present study standardization with the following parameters was newlineconducted: Loss on drying, pH total ash, acid insoluble ash, water soluble ash, newlineSulphated ash, water soluble extractive, alcohol soluble extractive, bulk density, newlineforeign organic matter, identification of heavy metal, microorganisms and pesticide newlineresidues. The quality control parameters were found in normal range given by WHO newlineand Ayurvedic pharmacopoeia of India. It shows the standard conditions were newlinefollowed during farming and manufacturing.ie. GAP (Good agricultural practices) and newlineGMP (Good manufacturing practices). newlineAfter standardization, the herbal preparations were evaluated for cell viability assays. newlineThe drugs i.e. Eucalyptus globulus wer