A Study on Prevalence of Multi Drug Resistant Extensively Drug Resistant and Pan Drug Resistant Bacterial Isolates from Different Clinical Samples in Tertiary Care Hospital

Abstract

ABSTRACT newlineAIM newline To detect the prevalence of multi drug resistant, extensive drug resistant and pan- newlinedrug resistant bacterial isolates in tertiary care hospital. newlineOBJECTIVES: newline Present study will help to know the prevalent drug-resistant bacterial strain and newlinetheir resistance pattern newline Close monitoring of drug-resistant strain that will help in the formulation of newlineantibiotic policy and infection control measure to reduce the incidence of newlineantimicrobial drug resistance. newlineMATERIALS AND METHODS newline1. newlineDesign of the Study: newlineThis prospective study was carried out at the Department of Microbiology at F.H newlineMedical College and Hospital in AGRA, Rajasthan newlineIn the laboratory, 500 samples were processed to identify MDR, XDR AND PDR newlineDifferent bacterial isolates processed and identification of MDR, XDR AND PDR and newlineits antimicrobial resistance pattern. newlineA total of 500 bacterial isolates were analysed for the isolation of antimicrobial newlinemedication resistance patterns. newline2. newlineObservations and result newlineThe study of 500 clinical samples revealed a significant predominance of Gram- newlinenegative bacilli, accounting for 74.2% of isolates, while Gram-positive cocci newlineconstituted 25.8%. newlineAntimicrobial Resistance Trends newlineMultidrug-Resistant (MDR), Extensively Drug-Resistant (XDR), and Pan drug- newlineResistant (PDR) Bacteria: Among 129 Gram-positive isolates, 65.1% were MDR, newlinevi newline34.8% were XDR, and no PDR strains were detected. Among 371 Gram-negative newlineisolates, 61.18% were MDR, 35.3% were XDR, and 3.5% were PDR. newlineResistance in Gram-Positive Bacteria: newlineStaphylococcus aureus was the most frequently isolated species, with 69.3% MDR newlineand 30.7% XDR strains, particularly affecting skin, soft tissue, and bloodstream newlineinfections. newlineCoagulase-Negative Staphylococci (CoNS), commonly implicated in device- newlineassociated infections, exhibited 60% MDR and 40% XDR. newlineEnterococcus species showed 59% MDR and 41% XDR, raising concerns about newlinevancomycin-resistant Enterococci (VRE). newline