Development of Bioactive Carbon Based Nanomaterials for Healthcare Application

Abstract

n the present era where scientific technology is growing and developing at an enormous pace, newlinenanoscience provides innumerable opportunities in material engineering. Nanomaterial science newlineinvolves the study of structures in which atleast one of the dimensions is in the nano size range. newlineCarbon nanomaterial (CBN) is an important member in the field of material sciences and newlinecontinues to be an area of interest for the scientists in the field of electronics, optical and newlinebiomedical sciences. The exceptionally good physicochemical properties, durability and newlinesensitivity of CBN has been explored in various healthcare applications. newlineBecause of novel optical and electronic properties and their ease of functionalization, carbon newlinenanostructures are expected to be used in several biomedical applications such as newlinenanoelectronics, live cell imaging, drug delivery, theranostics, tissue engineering and drug newlinedelivery. Realizing the enormous potential of carbon-based nanomaterials nanomaterials for newlinetheir applications in the field of medicine, I synthesized different carbon nanomaterials and newlineestablished their activity in cancer theanostics and wound healing dressings. newlineIn the present study, my focus will be on the development of two types of carbon nanomaterials newlinei.e carbon dots and graphene nanohybrid composites and exhibiting its application in newlinehealthcare. The first part of the thesis focuses on the synthesis, characterization and biomedical newlineapplication of carbon dots. In the first study, I explored the possibility of overcoming some of newlinethe limitations of natural compounds in bio-medical applications. I had used curcumin as a newlinemodel, as the molecule, despite its well-known therapeutic activity, has limited clinical newlineapplication in view of poor solubility and low bioavailability. The curcumin derived carbon newlinedots (CurCD) were synthesized with curcumin, with ethylenediamine, as a nitrogen source. newline