Design Synthesis and Biological Evaluation of Some Novel Sulfonamide Derivatives

Abstract

The current research work begins with the rational design of novel sulfonamide derivatives based on existing knowledge. The novel target molecules were designed using molecular hybridization techniques, which involve merging different biologically active molecules through chemical modifications within a single framework that enhances the biological properties of the resulting molecule. The different bioactive heterocyclic pharmacophores like benzisoxazole, L-proline, piperazine, piperidine, benzofuran, pyrazole, oxime, imine, and sulfonamide functionality were clubbed in a single framework to enhance the biological activity of the newly synthesized molecules. newline