Screening of Natural Products for management of Acute Lung Injury by evaluating its effect on Inflammatory and oxidative stress pathway

Abstract

The acute lung injury (ALI) or its clinical counterpart acute respiratory distress syndrome newline(ARDS) was first defined in 1967 (Ashbaugh et al., 1967) by a case-based report that newlinedescribed the clinical presentation of acute hypoxemia, non-cardiogenic pulmonary edema, newlinereduced lung compliance (increased lung stiffness), increased work of breathing, and the need newlinefor positive-pressure ventilation in critically ill adults and children in association with a newlinevariety of clinical disorders such as trauma, pneumonia, sepsis, and aspiration1. Specific newlinediagnostic criteria for the syndrome were established by an American European consensus newlineconference in 1992, and these criteria were updated in 2012 in the so-called Berlin definition newlineof ARDS in adults (Bellani et al., 2016). newline