Evaluation of Antiurolithiatic Potentials of Nerium Oleander l and Cucumis Sativus l in Rats

Abstract

Background: newlineABSTRACT newlineWorld Health Organization (WHO) has given a special attention to use medicinal newlineplants and their products for better health care of mankind. Hence medicinal plants act newlineby multiple mechanisms like, antioxidant, antimicrobial, anti-inflammatory and anti- newlineurolithiatic potentials. Presently urinary calculi invite a special attention from medical newlinefraternity due to the complexity in its pathogenesis as well as relapse rate. In the newlinemodern medicine, advanced equipments and surgical techniques have failed to trace newlineout the factors behind the urolithiasis and till today no advanced system that has been newlinedeveloped will have the capacity to remove or to avoid the recurrence of stone newlineformation. In the present scenario, whatever medications are preferred for the newlineeffective management of urolithiasis are invariably associated with undesirable effects newlinewhich ultimately results in termination of therapy by the patients. Hence, medicinal newlineplants has given a significant contribution for development of natural bioactive agents newlinewith more potent biological activity. newlineAim and Objectives: To evaluate anti-urolithiatic potential of Nerium oleander Linn. newlineand Cucumis sativus Linn. in ethylene glycol induced urolithiasis in experimental newlineanimals. Separation and identification of phytochemical agents from hydro- alcoholic newlineextracts with various chromatographic techniques. newlineMethodology: The selected Indian medicinal plants i.e. Nerium oleander Linn. and newlineCucumis sativus Linn were collected from Belagavi region. The extraction was newlineperformed by cold maceration technique with ethanol (95%) and water in the ratio of newline(70:30). The standardization parameters and preliminary phytochemical investigation newlinewere carried out for identification of phytoconstituents. The LD newlinexx newline newline50 newline cut off dose for newline newlinethe selected Indian medicinal plants Nerium oleander Linn and Cucumis sativus Linn newlinewere determined. The screening of lithotriptic effect of hydroalcholic extract of newlineNerium oleander Linn and Cucumis sativus Linn were evalua