Formulation Development and Evaluation of Fast Dissolving Film Containing Niosomes for the Treatment of Psychosis

Abstract

xviii newlineAbstract newlinePsychosis is the term used to describe a collection of mental symptoms, including a loss of some sense of reality. Niosomes were utilized to allow for pro- longed release of the drug, whereas the films were used to increase the drug s bioavailability via the sublingual route. newlineHPMC E15 was first dissolved in distilled water (DW). Add Saccharin sodium, Citric acid, FD and C yellow no. 6 and Menthol respectively in the polymeric solution. The calculated amount of Cross carmellose sodium was incorporated into the polymeric solutions after levigation with the required volume of the Glycerin. For the preparation of medicated films by Solvent casting methods is used.All films are clear transparent, yellow color, non-sticky with a smooth surface. The tensile strength was found in a range of 3.55-6.76 N/mm2. % elongation in between 56-208%. Folding endurance in a range of 148-220. In vitro drug release of chlorpromazine HCl was 94% and Haloperidol was 96%. Thickness of the film was in a range of 64- 101 and#956;m. Surface PH in between 6.23- 6.72. % moisture loss between 1.82- 3.56. % cumulative drug release highest for Chlorpromazine HCl 98.81% and Haloperidol 100.2 %. Ex- vivo permeability % cumulative drug release highest for Chlorpromazine HCl 90% in 2 hrs and for Haloperidol 91% in 24 hrs. newlineKeywords: Niosome, Sublingual film, Cumulative drug release, Release model, newline