Development of New Synthetic Approaches Towards the Total Synthesis of Biologically Active Natural Products

Abstract

We have developed enantioselective approaches for the synthesis of (+)-(2S,3S,5S)-epi- muscarine, (+)-nephrosteranic acid employing Sharpless AD and organocatalzyed Michael addition reactions as key steps. We have also attempted the synthesis of (-)- trachelanthamidine. The merits of these synthetic approaches are high enantio- and diastereoselectivity with high yielding reaction steps.