Neuroprotective effect of synthesized zinc oxide nanoparticle capped catechin

Abstract

Nanotechnology is a prolonged branch of existing research that involves the newlinefabrication and customization of particle structures with typical sizes of less than 100 nm. newlineA large area of surface-to-volume ratio was related to minimum surface functionalization, newlineresulting in nanostructured metal oxide nanoparticles with outstanding biological activity. newlineThe biosynthesis of nanoparticles has become an important research area because of their newlineremarkable environmental friendliness and biocompatibility. Catechin, a group of newlinepolyphenolic compounds is widely used as nutraceuticls, Zinc oxide in the form of newlinenanoparticles, can enhance beneficial therapeutic effects to the development of newlinenanotechnology shown to have neurogenic and neuroprotective effects, regeneration and newlinerepair of damaged brain tissue, cortical neurons synaptic connection and synaptic newlineplasticity and ultimately promote regeneration. Camellia sinensis is one of the most popular plants used in green tea production worldwide, which possesses the antioxidant and neuroprotective properties. The aim of this research is the synthesized zinc oxide nanoparticle-capped catechin and investigation of their neuroprotective potential. Zinc oxide nanoparticles synthesized form the Camellia sinensis leaf extract by nano precipitation method, then capped with catechin. The nanoparticles were characterized by different techniques, such as UV Vis spectrophotometer, Scanning electron microscopy, Zeta potential, Fourier transform infrared spectroscopy and X-ray diffraction analysis. newlineSynthesized zinc oxide nanoparticle-capped catechin exhibited the antioxidant activity was determined using the DPPH radical scavenging activity. Synthesized zinc oxide newlinenanoparticle-capped catechin has significantly inhibited the acetylcholinesterase activity. newlineA dose-dependent cell viability of synthesized zinc oxide nanoparticle-capped catechin has been observed against Neuro 2a cells.