Designing and Optimization of Fast Dissolving Tablets of Few Drugs

Abstract

Fast Dissolving Tablet (FDT) is one of the patient acceptable novel drug delivery system (NDDS) suitable for pediatrics and geriatics with easy administration of drug molecule. A fast dissolving tablet is the one which disintegrates or dissolve rapidly in saliva without the need of water or chocking. FDT usually dissolve in the oral cavity within 15 seconds to 3 minutes. In other words, fast dissolving tablet is a tablet that dissolves or disintegrates in the oral cavity without the need of water or chewing . Fast dissolving tablet is also called as orodispersible tablet, melt-in-mouth, rapid disintegrating tablet, repimelts, porous tablets and quick dissolving tablet . Their growing importance was underlined recently when European Pharmacopoeia adopted the term Orodispersible Tablets as a tablet that to be placed in the mouth where it disperse or disintegrate in less than three minutes . Aim of the Study: Fast dissolving drug delivery system originated from the desire to provide patient with more conventional means of taking their medication. Conclusion: Geriatric and pediatric patients suffer from dysphagia to conventional oral dosage forms leads to high incidence of non-compliance and ineffective therapy which was overcome by formulating fast dissolving tablets. Fast dissolving tablet dissolves or disintegrates in the oral cavity rapidly without the need of water or chewing. Fast dissolving tablet aims those drugs which undergoes extensive hepatic first pass metabolism makes them to bypass the route thereby increases the systemic bioavailability of such drugs. Hence, in the present study an attempt will be made to optimize the formulation of fast dissolving tablets of salbutamol sulphate and terbutaline sulphate for the treatment of asthma seperately using 3° full factorial design. This study also aims to compare the disintegrating efficiency of natural superdisintegrant, plantago ovata husk powder with synthetic superdisintegrant. crospovidone in two different concentrations of 2.5% and 5%.