Development Formulation Evaluation of Gastro Retentive Drug Delivery System For The Treatment of Peptic Ulcer

Abstract

Peptic ulcer disease refers to painful sores or ulcers in the lining of the stomach newlineor first part of the small intestine, i.e. duodenum. An ulcer in the stomach is known as a newlinegastric ulcer while that in the first part of the intestines is known as a duodenal ulcer. While newlineit is in the part of esophagus then is called as esophagus ulcer. newlineOral as well as systemic therapies are available in the treatment of peptic ulcer newlinewhich act either by inhibiting H pylori bacteria , by Inhibition of excess secretion of acid newlinein GIT or by neutralizing acid secretion. newlineBioavailability of antiulcer drug depends on gastric empting time, for better newlinebioavailability more gastric retention time is required; drug must be present extended newlinetime period at the affected area. newlineConsidering physiological factors in the stomach, it must be noted that, to achieve newlinegastric retention, the dosage form must satisfy certain requirements. One of the key issues is newlinethat the dosage form must be able to withstand the forces caused by peristaltic waves in the newlinestomach and the constant contractions and grinding and churning mechanisms. To function as newlinea gastric retention device, it must resist premature gastric emptying. Furthermore, once its newlinepurpose has been served, the device should be removed from the stomach with ease. newlineTo extend the time spent in the stomach one of the finest ways is gastro newlineretentive drug delivery, which targets site specific drug release in the stomach for local newlineor systemic effects. Over past few decades, Peptic ulcer disease remains a common newlinecondition despite the lots of novelty in treatment. The objective of this research work was newlineto formulate gastro retentive floating tablet by raft approach using Pirenzepine newlinedihydrochloride (PNZ) as drug candidate. Formulation also contained a raft forming agent newline(sodium alginate) along with alkalizing agents (Calcium carbonate and Sodium newlineBicarbonate). Raft strength was only affected by the amount of Raft forming agent, newlineCalcium carbonate and Sodium Bicarbonate. Drug-excipients compatibility study showed newlineno