Phytochemical and antiamnesic activity investigatons of alternanthera pungens kunth

Abstract

close scrutiny of literature available in various scientific databases suggested newlinethe presence of phenolic as well as flavonoidal compounds as major classes of newlinecompounds in plant A. pungens. The review of literature suggested that no newlinepharmacological research work related to investigate antiamnesic action of plant, newlineso it is planned to evaluate the antiamnesic activity of the plant. Thus, the present newlineresearch work will be planned to isolated antiamnesic compounds by bioactivitydirected- newlinefractionation using sophisticated chromatographic technologies. Various newlinepharmacognostic standards including qualitative and quantitative microscopic newlinecharacters, physico-chemical parameters, TLC fingerprint profiles, phytochemical newlinescreening and toxic residue content were generated for A. pungens aerial parts.. newlineColumn chromatography of the ethyl acetate fraction produced six pooled newlinefractions (F1 F6) were tested for acetylcholinesterase inhibitory activity. For newlinecrystallization, the prepared clear solution was left overnight. From the solution, newlinethe yellow crystalline powder (APV-1; 210 mg) was extracted. the chemical newlinestructure of APV-1, which was determined to be caffeic acid based on physical newlineappearance, UV, NMR, and IR spectrum data. newline