Relationship Between Lipid Profile and Inflammatory Markers in Type2 Diabetes Mellitus and Acute Ischemic Stroke A Multigroup Comparison Study

Abstract

Diabetes Mellitus is a chronic metabolic disorder characterized by persistent newlinehyperglycemia resulting from impaired insulin production, insulin resistance, or both. newlineType 2 diabetes, comprising 90-95% of cases, is a complex interplay of genetic, newlineenvironmental, and lifestyle factors. DM is a significant risk factor for cardiovascular newlinedisease and cerebrovascular disease. Stroke, a devastating cerebrovascular disease newlinewith neurological complications, is a leading cause of morbidity and mortality newlineworldwide. Ischemic stroke, the most common form, arises from a blood clot newlineobstructing a cerebral artery, leading to brain tissue deprivation. Both diabetes and newlinestroke impose a significant global health burden, often resulting in long-term newlinedisability. The relationship between inflammatory markers and lipid ratios in Type 2 newlineDiabetes (T2DM) and Acute Ischemic Stroke (AIS) is a complex and multifaceted newlinetopic involving various physiological processes. Both T2DM and AIS are associated newlinewith chronic inflammation, and understanding the relationship between inflammatory newlinemarkers and lipid ratios can reveal insights into the pathophysiology and possible newlinetherapeutic targets for these conditions. Chronic inflammation is a shared pathological newlinefeature of diabetes and stroke, contributing to insulin resistance, endothelial newlinedysfunction, and increased cardiovascular risk. The present study assesses the newlinerelationship between inflammatory markers such as NLR, PLR, and CRP and lipid newlineprofile ratios such as TG/HDL-C and TC/HDL-C in T2DM and AIS. newline