Development and Optimization of Novel Topical Drug Delivery System for management of Diabetic Foot Ulcer

Abstract

Diabetic foot ulcer (DFU) occurs in nearly 35% of diabetic population. The global occurrence rate newlineof foot ulcers or infection among diabetic population has increased from 3% to 13%. Owing to the newlinelong cycle and high cost with respect to wound treatment, developing efficacious and economical newlinetreatment is urgent and imperative in clinical practice of DFU. newlineBacterial infection is among the most common and severe complications in the management of newlineDFU. Topical antimicrobial preparations are often used for management of diabetic foot newlineulcers. Silver based topical products are currently being used as the first line approach for newlinemanagement of DFU in outpatients. Several topical antimicrobial products are commercially newlineavailable that use silver either in colloidal form or as Nanoparticles. Growth factors are another newlinemajor treatment option which is highly effective in management of deep wounds associated with newlineDFU; however their high cost limits its usage. newlineThe regulation of oxidative stress is important factor that plays a major role in successful wound newlinehealing in DFU; however, it has often been overlooked in the development of wound dressings. newlineThe inflammation phase plays an important role in wound healing, representing the rate and the newlinequality of tissue repair. During this phase, an elevated level of reactive oxygen species (ROS) from newlineinflammation may lead to excessive oxidative stress, induce apoptosis, and impair the healing newlineprocess. newlineThe use of topical antimicrobial agents for infection control and antioxidant in wound dressings newlineare promising strategies for management of DFU. However, only a few studies have sought to newlinedevelop products that have both these properties. newline