SYNTHESIS CHARACTERISATION AND BIOLOGICAL EVALUATION OF SUBSTITUTED SPIRO OXINDOLES PYRAZOLE and#945; AMINO PHOSPHONATES AND ACENAPHTHYLENE PYRROLIDINES

Abstract

Modern drug discovery and development plays a vital role in transforming a molecule from laboratory into a drug candidate and is a high priority contribution from a scientific community In this context the drug discovery process can be broadly segregated into two segments Identification and optimization of lead molecules to enhance their selectivity towards the target including their toxicity profile Development of a relevant biological system to test the compounds in vitro and in vivo models to speed up the drug discovery process and to improve the screening efficiency and success rate Heterocyclic compounds constitute an important area in organic chemistry Novel heterocycles designed and produced synthetically by organic chemicals are used as agrochemicals and pharmaceuticals Nitrogen and oxygen contains heterocycles are by far the most widely occurring To substantiate the above statements the research attempt has been undertaken to frame the strategy as per the protocol of drug discovery to Design synthesis new chemical entities of diverse heterocyclic scaffolds like Spiro oxindole SV Pyrazole and#945; amino phosphonates PV and Acenaphthylene Pyrrolidine VAZN analogues and screening for anti cancer activity because highly reputed research organisations like CSIR CLRI working on hard synthetic strategies but have left many compounds without exploring for its biological activity So there is a real scope for those compounds when hunted to investigate as a anti cancer drug candidate in future newline