Design synthesis and biological applications of amino acid oligonucleotide based nanoconjugates

Abstract

The potential of nanobiotechnology has been effectively harnessed to tackle two critical challenges: heavy metal pollution and antimicrobial resistance (AMR). This research presents the development of a highly sensitive fluorescence-based aptasensor for arsenic detection, showcasing enhanced versatility and sensitivity compared to traditional biosensors. Additionally, peptide-capped silver nanoparticles and self-assemblies based on single amino acids were synthesized to combat antimicrobial resistance. The results demonstrated that these materials exhibited efficient antimicrobial properties, facile synthesis, structural diversity, stability, biocompatibility, and cost-effectiveness. Nanobiotechnology, which utilizes nanoparticles and biomolecules, offers innovative newlinesolutions across various fields. This work explores its application in addressing pressing challenges such as heavy metal contamination and AMR. The development of a sensitive arsenic biosensor using fluorescent CdTe quantum dots with an arsenic-specific aptamer exemplifies advancements in this area, accommodating a broader range of analyte concentrations without compromising sensitivity. Furthermore, the investigation into antimicrobial strategies revealed that arginine-based newlineself-assemblies possess inherent antimicrobial properties, making them a promising strategy for targeted delivery and improved efficacy against AMR. These self-assemblies are characterized by their easy synthesis and structural diversity, contributing to their stability and biocompatibility. Collectively, this research presents a promising strategy for the detection of diverse analytes and the development of novel biomaterials. By significantly improving efficacy in addressing environmental pollution and combating antimicrobial resistance, nanobiotechnology stands at the forefront of innovative solutions for these global challenges. newline newline