Design development and optimization of gastroretentive drug delivery system using anti ulcer drugs

Abstract

quotDESIGN DEVELOPMENT AND OPTIMIZATION OF GASTRO RETENTIVE DRUG DELIVERY SYSTEM USING ANTIULCER DRUGS newlineSubmitted by: Borade Amol Uttamrao, Ph.D. Scholar, RK University, Rajkot, Gujarat newlineSupervised by: Dr. Ketan Shah, Principal and Professor, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh. newlineFor the treatment of gastrointestinal ulcers, raft-forming systems incorporating nizatidine were developed to provide sustained drug release and prolong gastric residence time. The raft-forming formulations contained Nizatidine, Isabgol, and Sodium Alginate as gelling polymers, sodium bicarbonate as an agent to generate gas, and calcium carbonate as an agent to strengthen gels. Sodium bicarbonate, along with divalent Ca++ ions, forms a floating raft loaded with drugs. Raft formulation was optimized by applying a full factor design of 33. Testing was done on all batches for pH, in vitro flotation, raft strength, acid neutralizing capacity, viscosity, and drug release for optimized batches. Most formulations using isabgol and sodium alginate as gelling agents have a gelled raft in less than 2 minutes and remain buoyant for more than 8 hours in 0.1 N hydrochloric acid with a pH of 1.2. Optimized batches show good administration capabilities and better stability over six months. The studies conducted suggested that raft-forming systems made from natural polymers carrying drugs could be used to deliver gastroretentive drugs.quot newline