Synthesis and Biological Evaluation of Novel Triazolyl Acridine Derivatives as Cytotoxic Agents

Abstract

Synthesis and Biological Evaluation of Novel Triazolyl-Acridine Derivatives as newlineCytotoxic Agents newline1. INTRODUCTION newline1.1. ACRIDINES newlineAcridine is a heterocyclic organic compound containing a nitrogen hetero atom, with the newlineformula C13H9N. Acridines are the compounds introduced since 19th century. This newlinesubstance Acridine was isolated from crude Anthracene and then named as Acridine newlinebecause of its irritating odor and it had itching and inflammatory properties. Also newlineAcridine means sharp, painful. Structurally, Acridine is 2, 3, 5, 6-dibenzopyridine, or newlinedibenzopyridine or 10-azaanthracene. It is also found in plants as alkaloid. Physically, newlineAcridine characterized as colorless to light yellow needles shape crystals having melting newlinepoint of 110°C and boiling point of 346°C with characterstic odor causes irritation. It also newlinecauses irritation on skin surface and solutions of its salts showed the blue fluorescence. newlineStructurally, Acridines are the linear fusion of three planer 6-membered aromatic rings newlinewith a hetero nitrogen atom included in the center ring. Acridine derivatives are able to newlineinteract with DNA by its base pairs. newline