Design And Development Of Novel Drug Delivery System For The Topical Treatment Of Onychomycosis

Abstract

Abstract: newlineDifferent antifungal loaded novel emulgels containing several permeation enhancers were formulated for transungualdrug deliveryfor the management of onychomycosis, which affects the nails. The physicochemical properties like droplet size, zeta potential, pH, viscosity, spreadability, extrudability, oil binding capacity, drug content, and microscopic study were evaluated. The Pseudo-ternary phase diagram was constructed for the development of novel emulsions and characterized for clarity, mean droplet size, zeta potential, viscosity, pH, transmittance, refractive index, and stability. The mean droplet size determined for LCZ, KCZ and AmB loaded novel emulsions and found in the range 38.78-171.4, 47.62-192.10 and 172.16-284.12 nm, respectively. Determined zeta potential for LCZ, KCZ and AmB novel emulsions was in the range of 0.00 to -6.6, -0.6 to -6.1 and - 0.41 to -4.2 mV. Prepared emulsions were converted into novel emulgels by adding different concentration of the gelling agent in the external phase, and a drug release study was conducted. Formulation with better drug release was chosen as control formulation. Different penetration enhancers were added separately in the optimized novelemulgels and further evaluated for pH, viscosity, spreadability, extrudability, oil binding capacity, drug content, microscopic study, Compatibility study, XRD, DSC and stability. Encouraging docking scores of Luliconazole and Ketoconazole was observed against Lanosterol 14-alpha-demethylase, In-vitrodrug release study suggested that the novel emulgels containing sodium sulfide as penetration enhancer, showed better drug release, which was almost double than the control formulations. Ex-vivo transungual permeation studies were conducted with LCZ, KCZ and AmB emulgels through cutting nail clippings and drug uptake were found to be in the range of 28.18 - 36.52, 108.42-119.43and 32.24 - 46.91 and#956;g/mm2, respectively. All the optimized newline2 newlinenovel emulgels showed significant zone of inhibition against fungus strains as compared t